Have scientists just found a cure for baldness? [JAK]

Have scientists just found a cure for baldness?

Ashitha Nagesh forMetro.co.uk Sunday 25 Oct 2015 4:27 pm
Source: metro.co.uk

(Picture: Getty Images)

Scientists have developed a new drug that could be a cure for baldness.

The treatment caused bald mice to regrow their hair in just three weeks – and it’s been shown to work on human hair follicles too.

The drug inhibits the Janus Kinase (JAK) family of enzymes inside hair follicles that are suspended in a resting state – essentially ‘waking’ the hair up.

‘What we’ve found is promising, though we haven’t yet shown it’s a cure for pattern baldness’ Dr Angela Christiano from Columbia University, said.

‘More work needs to be done to test if JAK inhibitors can induce hair growth in humans using formulations specially made for the scalp.’

Dr Christiano and her team accidentally discovered the effect of JAK inhibitors on hair follicles while studying alopecia areata, an autoimmune disease that causes hair loss.

She noticed the mice grew more hair when a drug they were testing was applied onto the skin, rather than when it was given systemically.

When they looked closer, the researchers realised the inhibitors awakened resting follicles out of dormancy.

(Picture: Columbia University)

Mice treated for five days with a JAK inhibitor grew new hair within just 10 days. In the same time, the control mice didn’t grow any.

‘There aren’t many compounds that can push hair follicles into their growth cycle so quickly,’ Dr Christiano added.

‘Some topical agents induce tufts of hair here and there after a few weeks, but very few compounds have this potent an effect so quickly.’

They then tested the drug on human hair follicles grown in culture and on skin grafted onto mice, and it had the same effect.

Researchers are now looking at its effect on hair follicles affected by hair loss disorders.

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Scientists' 'vampire treatment' for baldness

Scientists' 'vampire treatment' for baldness

By Jasper Copping
7:30AM BST 05 May 2013
Source: telegraph.co.uk

Scientists believe among others the treatment
 could help male-pattern baldness (Photo: gettyimages.com)

Scientists believe they may have hit upon a cure for baldness — but it is not for the faint-hearted.

Researchers found they were able to regrow hair on the bald patches on people’s heads by injecting them with a solution derived from their own blood.

The so-called “vampire” treatment involved taking blood from the patient and processing it in a machine that extracts “platelet-rich plasma” (PRP), which is then injected back into the head.

Scientists believe the solution then stimulates new stem cells below the skin which can aid the regrowth of hair.

Such “vampire” treatments are already used in some cosmetic procedures, where injections of PRP are used in an effort to reduce the effects of aging on the face and hands.

The new treatment could have helped Sir Elton John who invested in a hair transplant.

The research, published in the latest edition of the British Journal of Dermatology, was conducted among a group of people suffering from alopecia areata, which affects about 2 per cent of the population.

However, the scientists believe it could also help those suffering more common varieties, such as male pattern baldness. Dr Fabio Rinaldi said: “We think it can help to regrow hair on people with androgenic alopecia (male pattern baldness). We believe it is the best treatment available, apart from surgery.”

The study involved 45 patients, who received the injections on just one half of their head. Some were given the PRP, some were given a more traditional steroid treatment, while others received a placebo.

A total of three treatments were given to each patient, once a month. Hair growth was assessed by measuring the area where new hairs grew on the bald scalp. The PRP was found to lead to significant hair regrowth in the bald patches, compared with both the placebo and the steroid treatment.

The scientists, based at the International Hair Research Foundation and University of Brescia in Italy and the Hebrew University Medical Centre in Israel, are carrying out further research. They hope to be able to develop the treatment as a cream, to avoid the need for needles.

Nina Goad, of the British Association of Dermatologists, said: “Alopecia is known to lead to overwhelming effects on the patient’s quality of life and self-esteem. This could offer hope to thousands.”

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