Showing posts with label regeneration. Show all posts
Showing posts with label regeneration. Show all posts

Sunday, January 24, 2016

Top Hair Loss Treatments Make a Futuristic Fight for Your Follicles

Top Hair Loss Treatments Make a Futuristic Fight for Your Follicles


By Mark Ellwood 2014-12-24 T17:09:56Z
Source: bloomberg.com
Photographer: Marton Perlaki/Bloomberg

There were five of us at the bar that night—all old friends—when I absent-mindedly raked a hand through my hair. Like my father before me, I’ve always had plenty on top. My coarse, thick hair is graying at the temples, sure, but it isn’t yet receding. One friend warned me not to tug too hard. “Even those pills have limits,” he said.

“Who needs pills?” I asked. “We’ve all got a full head of hair.” At which point, conversation screeched to a halt, as though I’d just asked the size of everyone’s bonus. It fell to another friend to break the silence and admit he was celebrating his 10th anniversary with the 5-alpha-reductase inhibitor known as Propecia (now available in generic form as finasteride). The three others followed suit with similar confessions.

Gradually, it emerged that by the time we’d finished college, mine was the only hairline that hadn’t benefited from a doctor’s prescription. Should my good genes one day fail me, however, all is far from lost. A survey of dermatologists, inventors, scientists and surgeons reveals a comforting truth: There has never been a better time to find too much hair on your brush. Here are the top treatments from the rapidly advancing front (hair)lines.

The Magic Pill: Finasteride

The new generic form of Propecia carries warnings of unpleasant side effects (one of which is treatable with that other little blue pill, Viagra). But in terms of success stories—88 percent of men experience no additional hair loss; 58 percent experience regrowth—no other treatment comes close.

Laserlike Focus: iGrow

This helmut full of lasers looks like something out of SkyMall but was nevertheless approved by the U.S. Food and Drug Administration. The lasers act like a shot of Red Bull, forcing follicles to step up their productivity. Although the over-the- counter device is just $695, treatment involves six straight months of daily 25-minute sessions (hence the built-in headphones). The return, according to Dr. Abraham Armani, a Dallas-based hair-transplant surgeon, is a not-quite- market-beating 7 percent increase in hair density. igrowlaser.com

HAL for Hair: Artas Robotic Hair Transplant

The problem with so-called strip hair transplants—in which sections of scalp are harvested from the follicle-rich rear of the head in order to replenish the hairline at the front—is that they often result in Frankenstein-like scarring. The Artas system, on the other hand, employs a robotic arm that extracts and transplants individual follicles, minimizing discernible damage. “You’re removing 30 to 45 percent less skin, which means much more rapid recovery,” says Dr. Barry Goldman of New York–Presbyterian Hospital/Weill Cornell Medical Center. “Within a day or two, you’ll feel like nothing ever happened.” artashair.com

True Blood: Platelet-Rich Plasma Therapy

During this post-transplant procedure, your own blood is extracted, centrifuged and then slathered onto the scalp, increasing the survival rate of new follicles and speeding the proliferation of new strands. “You will get results about six months faster,” Armani says. “And the hairs that do survive will be thicker and healthier.”

The Holy Grail: Hair Cloning

Inside each follicle, certain cells act like traffic cops, greenlighting the production of more hair, explains Colin Jahoda, a professor of stem-cell sciences at the U.K.’s Durham University. Regeneration involves tricking those cells into growing your own hair in a petri dish for transplant. Although the cells have thus far failed to cooperate outside the human body, Jahoda remains optimistic. How far off are viable clinical trials? “About five years,” he says, with the confident air of a man with all his own hair.

Article originally appeared in the Holiday 2014 issue of Bloomberg Pursuits.

Saturday, September 5, 2015

Bald truth: plucking hair out can stimulate growth, study finds

Bald truth: plucking hair out can stimulate growth, study finds


Hannah Devlin, science correspndent
@hannahdev Thursday 9 April 2015 17.02 BST Last modified on Thursday 9 April 2015 17.03 BSTSource: theguardian.com  

Although it seems counterintuitive, tests indicate that plucked follicles ‘communicate’, causing an immune response that leads to regrowth


Could this discovery be used to tackle baldness and alopecia? 
Tests are at an early stage, but could provide a solution in the future. Photograph: Asger Carlsen/Getty Images

Baldness is often dreaded by men and there are few, if any, satisfactory options for reversing it. Now scientists have discovered a potential solution, after showing that plucking hair out could actually stimulate growth.

The counterintuitive discovery, in mice, demonstrates a previously unknown method for triggering hair regeneration. Although the work is at an early stage, the authors believe the same process could be helpful for tackling hair loss in men or people with alopecia.

Philip Murray, of Dundee University and a co-author, said the findings now need to be tested in people. “It would be a bit of a leap of faith to expect this to work in bald men without doing more experiments,” he said.

The study found that when hairs were plucked in a specific configuration, follicles in the skin were prompted to send out a “distress” signal that led to even more hairs growing back. Plucking our 200 hairs triggered the growth of up to 1,200 replacement hairs in the mice, the study found.

Tests showed that the plucked follicles signal distress by releasing inflammatory proteins, which cause immune cells to rush to the site. In turn, these send out signals to all neighbouring follicles indicating that it is time to grow more hair.

“We’ve made a discovery about how hair communicates when it’s distressed,” said Murray.

The study, published in the journal Cell, showed that the pattern in which the hair was plucked played an important role in the strength of the “distress” signalling process. The researchers tested this by plucking 200 hair follicles, one by one, in different configurations on the back of a mouse. When plucking the hairs in a low-density pattern from an area more than six millimetres across, no hairs regenerated. However, higher-density plucking from circular areas with diameters between three and five millimetres triggered the regeneration of between 450 and 1,300 hairs – and the regeneration sometimes spilled out beyond the plucked area.

The authors believe that hair follicles do not simply respond individually to being plucked, but also communicate between themselves - something called “quorum sensing” - and effectively make a group decision about the level of immune response that is necessary. In the case of widely spaced plucking, the follicles are too far apart to be able to signal collectively. However, when the damage is tightly packed a more extreme response is mounted, leading to much stronger hair regrowth.

A potential drawback in balding men might be that their hairs are already too sparsely spaced for the approach to be helpful.

“It is a good example of how basic research can lead to a work with potential translational value,” said Cheng-Ming Chuong, professor of pathology at the University of Southern California and lead author.