Showing posts with label stem cells. Show all posts
Showing posts with label stem cells. Show all posts

Sunday, January 24, 2016

Top Hair Loss Treatments Make a Futuristic Fight for Your Follicles

Top Hair Loss Treatments Make a Futuristic Fight for Your Follicles


By Mark Ellwood 2014-12-24 T17:09:56Z
Source: bloomberg.com
Photographer: Marton Perlaki/Bloomberg

There were five of us at the bar that night—all old friends—when I absent-mindedly raked a hand through my hair. Like my father before me, I’ve always had plenty on top. My coarse, thick hair is graying at the temples, sure, but it isn’t yet receding. One friend warned me not to tug too hard. “Even those pills have limits,” he said.

“Who needs pills?” I asked. “We’ve all got a full head of hair.” At which point, conversation screeched to a halt, as though I’d just asked the size of everyone’s bonus. It fell to another friend to break the silence and admit he was celebrating his 10th anniversary with the 5-alpha-reductase inhibitor known as Propecia (now available in generic form as finasteride). The three others followed suit with similar confessions.

Gradually, it emerged that by the time we’d finished college, mine was the only hairline that hadn’t benefited from a doctor’s prescription. Should my good genes one day fail me, however, all is far from lost. A survey of dermatologists, inventors, scientists and surgeons reveals a comforting truth: There has never been a better time to find too much hair on your brush. Here are the top treatments from the rapidly advancing front (hair)lines.

The Magic Pill: Finasteride

The new generic form of Propecia carries warnings of unpleasant side effects (one of which is treatable with that other little blue pill, Viagra). But in terms of success stories—88 percent of men experience no additional hair loss; 58 percent experience regrowth—no other treatment comes close.

Laserlike Focus: iGrow

This helmut full of lasers looks like something out of SkyMall but was nevertheless approved by the U.S. Food and Drug Administration. The lasers act like a shot of Red Bull, forcing follicles to step up their productivity. Although the over-the- counter device is just $695, treatment involves six straight months of daily 25-minute sessions (hence the built-in headphones). The return, according to Dr. Abraham Armani, a Dallas-based hair-transplant surgeon, is a not-quite- market-beating 7 percent increase in hair density. igrowlaser.com

HAL for Hair: Artas Robotic Hair Transplant

The problem with so-called strip hair transplants—in which sections of scalp are harvested from the follicle-rich rear of the head in order to replenish the hairline at the front—is that they often result in Frankenstein-like scarring. The Artas system, on the other hand, employs a robotic arm that extracts and transplants individual follicles, minimizing discernible damage. “You’re removing 30 to 45 percent less skin, which means much more rapid recovery,” says Dr. Barry Goldman of New York–Presbyterian Hospital/Weill Cornell Medical Center. “Within a day or two, you’ll feel like nothing ever happened.” artashair.com

True Blood: Platelet-Rich Plasma Therapy

During this post-transplant procedure, your own blood is extracted, centrifuged and then slathered onto the scalp, increasing the survival rate of new follicles and speeding the proliferation of new strands. “You will get results about six months faster,” Armani says. “And the hairs that do survive will be thicker and healthier.”

The Holy Grail: Hair Cloning

Inside each follicle, certain cells act like traffic cops, greenlighting the production of more hair, explains Colin Jahoda, a professor of stem-cell sciences at the U.K.’s Durham University. Regeneration involves tricking those cells into growing your own hair in a petri dish for transplant. Although the cells have thus far failed to cooperate outside the human body, Jahoda remains optimistic. How far off are viable clinical trials? “About five years,” he says, with the confident air of a man with all his own hair.

Article originally appeared in the Holiday 2014 issue of Bloomberg Pursuits.

Sunday, January 17, 2016

Re-seeding hairlines with stem cells

Re-seeding hairlines with stem cells

22 December 2015 Suzanne Howson
Source: rsc.org

Scientists in China and Canada have developed a way to treat hair loss using stem cells. The cells are enclosed within a cytokine-containing layer that circumvents the difficulties in regenerating new hair follicles on bald skin.

(click on image to enlarge) Hu's and Xing's teams coated the stem cells with serval
 polymer layers to both protect them and provide them with hair-inductive properties










Hair loss, or alopecia, is a common problem caused by aging, diseases and medicines. Although not life-threatening, the emotional effects of hair loss can be damaging. Currently, treatments include drugs and hair transplants, however these are expensive and regenerating new hair follicles after treatment remains challenging. Dermal papilla cells, a type of mesenchymal stem cell located in hair follicles, are responsible for hair-follicle morphogenesis and hair cycling. Although potentially useful for treating alopecia, they suffer from loss of function in vitro.

A team lead by Zhi-Qi Hu from the Nanfang Hospital of Southern Medical University, China, and Malcolm Xing from the University of Manitoba, Canada, has designed what Xing describes as ‘nutritious nano-clothing’. This creates a protective microenvironment for dermal papilla cells, and at the same time provides the cells with a source of fibroblast growth factor-2, an essential cytokine culture nutrient that enhances proliferation and hair-inductive properties.

The team used layer-by-layer self-assembly deposition to encapsulate the cells within an inner layer of gelatin, a middle layer of alginate loaded with fibroblast growth factor-2, and an outer layer of gelatin. Tests on nude mice showed that the implanted encapsulated cells caused abundant hair growth with the hair follicle organisation showing mature characteristics. The coating improved the intrinsic therapeutic effect of the stem cells by preserving the native extracellular matrix that the cell produces, and sustaining release of the cytokine. Xing recalls that the most challenging aspect of this work was ‘optimising the concentrations of the coated polymers and manufacturing conditions to make the cells happy and healthy’.

Oommen Varghese, an expert in regenerative medicine from Uppsala University in Sweden says: ‘This is fascinating science that has enormous potential for clinical translational of stem cell based regenerative medicine. Such a coating could also protect cells from innate immunity, thereby improving the in vivo survivability. This is a major challenge in stem cell based translational research.’ Xing is currently trying to move the technology from the bench to the bedside.

REFERENCES

B Lin et al, J. Mater. Chem. B, 2016, DOI: 10.1039/c5tb02265g

Wednesday, September 2, 2015

Bioengineered Follicles Grow Hair On Bald Mice

Bioengineered Follicles Grow Hair On Bald Mice


Published: Saturday 21 April 2012 at 12am PST
Source: medicalnewstoday.com


In a proof of concept study for bioengineered organ replacement, researchers in Japan made hair follicles derived from adult stem cells interact with surrounding tissue and show normal hair cycles, when transplanted into the skin of bald mice.

Takashi Tsuji, a Professor in the Research Institute for Science and Technology, Tokyo University of Science, and Director of Organ Technologies Inc, led the team, who report their findings in an open access paper published in Nature Communications on 17 April.

The study is significant on two counts: first it used adult stem cells and not embryonic stem cells, and second, the bioengineered follicles were fully functional and integrated into surrounding tissue, something that has not been managed before.

Not only does the study raise hopes of a cure for baldness, the researchers say it also represents a significant advance toward the next generation of "organ replacement regenerative therapies" that will enable the replacement of organs damaged by disease, injury or aging.

The researchers bioengineered hair follicle germ cells, the cells that mature into cells that grow hair, from two other types of cell: adult epithelial stem cells and dermal papilla cells.

They implanted the bioengineered cells into the skin of hairless mice and showed that they went on to have normal hair cycles, where after dead hairs fell out, new ones took their place.

The cells also showed other signs of normal functioning, such as piloerection, where the hair "stands on end" as a result of contraction of tiny surrounding muscles.

The authors write that the bioengineered follicles showed these restored functions "through the rearrangement of follicular stem cells and their niches". This is important because the "niches", a loose term to describe the microenvironment of stem cells, are what regulate normal stem cell behavior: for instance, they decide when to wake up stem cells to mature into fully formed follicles.

As well as demonstrating normal functioning, the bioengineered hair follicles developed the correct structures and made the right connections with surrounding tissue, including the epidermis, arrector pili muscles (the ones that produce piloerection) and nerve fibers.

The authors write:

"... our findings indicate that it is possible to not only restore a hair follicle but also to re-establish successful connections with the recipient skin by intracutaneous transplantation of the bioengineered follicle germ."


In their discussion they conclude:

"These findings significantly advance the technological development of bioengineered hair follicle regenerative therapy", and make a substantial contribution that will "enable future regenerative therapy for hair loss caused by injury or by diseases such as alopecia and androgenic alopecia".

They call for further studies to find out how to optimize human hair follicle-derived stem cell sources for clinical applications, and for further investigations of stem cell niches, as these will contribute to the "development of hair regenerative therapy as a prominent class of organ replacement regenerative therapy in the future".


Wednesday, December 10, 2014

Stem cells hold new hope for baldness

Stem cells hold new hope for baldness

Updated: December 8, 2014 09:22 IST
G. RAVIKIRAN
Source: thehindu.com



New procedures are being evolved in different therapies and surgical methods to extend the benefits of stem cell research and its applications to the needy people with better and effective results. “This has not only revolutionised bio-technology sector as a whole but also contributed immensely to the therapeutic procedures in a variety of areas. Cosmetology is no exception to this and people are deriving lot of benefit out of this,” said cosmetologist Dr. G. Radhika Reddy.

Addressing an awareness meeting held at their newly established Angels Advanced Clinic at Ramalingapuram here on Sunday, Dr. Reddy said the biggest advantage with the Stem cells cause a healthy multiplication of cells in a specific part of the body where it would be introduced. This had indeed become a boon for the public seeking natural relief from various illnesses including skin and hair related disorders. In the case of chronic problem of hair loss, Dr. Radhika said that the stem cell would be injected into the scalp in the form of a liquid.

It would reactivate the weakened hair roots leading to re-growth and new growth of hair.

Sunday, June 8, 2014

RepliCel Life Sciences’ Licensing Partner, Shiseido, Opens Cell Processing and Expansion Facility in Japan to Advance RCH-01, a Treatment for Pattern Baldness

RepliCel Life Sciences’ Licensing Partner, Shiseido, Opens Cell Processing and Expansion Facility in Japan to Advance RCH-01, a Treatment for Pattern Baldness


May 20, 2014
Source: replicel.com 


“Shiseido has been working diligently on the construction of their facility and we congratulate them on their efficiency and commitment to building a world-class cell research and development centre capable of handling all aspects of the RCH-01 technology from hair follicle biopsy through to cell replication and patient treatment,” commented David M. Hall, CEO of RepliCel Life Sciences. “We continue to support Shiseido with its highly focused development towards commercialization of RCH-01 as a treatment for pattern baldness.”
The KBIC is a complex of medical-related industries located on the 833-hectare man-made island of Port Island in Kobe, Japan. Working in cooperation with academic research institutions, government organisations, and industry, the island has been developed as a focal point for research and development of highly advanced medical technologies with the goal of streamlining processes from research to clinical application and commercialization.
Regenerative medicine in Japan is an emerging industry which the government has designated as an important part of its economic reform. Legislative support has come from the introduction of new laws to expedite otherwise lengthy clinical research and trial application processes to promote competitive advantage in the international market. In November 2013, as one of the new economic reform strategies, the Japanese government passed the Regenerative Medicine Law, which ensures safety of regenerative medicine, and approved revisions to its existing Pharmaceutical Affairs Law to improve the timelines for the development of regenerative medicine and to promote commercialization. Shiseido has entered into this field via its licensing agreement with RepliCel and is committed to its advancement and success.
Licensing Agreement
On July 11, 2013, RepliCel and Shiseido announced the completion of a Collaboration and Technology Transfer Agreement, giving Shiseido an exclusive geographic license to use RCH-01 hair regeneration technology in Japan, China, South Korea, Taiwan and the ASEAN countries Shiseido and RepliCel will collaborate on the continued improvement of the technology and will conduct human clinical trials in each of their territories with the goal of commercializing a safe and effective hair regenerative treatment to help those suffering from pattern baldness and thinning hair.

RCH-01 has been developed over 10 years of scientific research, and safe application in humans was validated during RepliCel’s phase 1 clinical trial. RepliCel has patents issued for hair follicle mesenchymal stem cells and their usage in Japan, the United States, Australia and the EU. RCH-01 is an autologous cell-based hair regenerative technology whereby specific hair follicle cells are isolated from a scalp biopsy, expanded in culture at a cell processing facility and injected back into patients.

About the Kobe Biomedical Innovation Cluster and Shiseido’s Facility
More than 260 domestic and international companies have built R&D facilities focusing on regenerative medicine, pharmaceuticals, medical equipment and devices in the research park, taking advantage of the opportunities for collaboration and synergy that the KBIC fosters. Centralised support services facilitate clinical research, commercialisation, consultations on pharmaceutical development issues and financing, and the establishment of comprehensive platforms for biomedical research and development. The Business Support Centre for Biomedical Research Activities has been built to support and to provide space for research and commercialization of regenerative medicine. This facility is divided into two sections, research and cell-processing. Shiseido’s Cell-Processing and Expansion Centre (SPEC) is located in the cell processing section, Room 620, 1-5-5 Minamimachi, Minatojima, Chuoku, Kobe, 650-0047, Japan.

About RepliCel Life Sciences
RepliCel is a regenerative medicine company focused on developing autologous cell therapies that treat functional cellular deficits including chronic tendinosis, pattern baldness and skin aging. Initiation of Phase 2 trials are planned for 2014 on RepliCel’s RCT-01 treatment for Achilles tendinosis and RCH-01 treatment for pattern baldness. Shiseido Company, Limited has an exclusive geographic license for RCH-01 in certain Asian countries including Japan, China and South Korea. Both product candidates are based on RepliCel’s innovative technology which utilizes cells isolated from a patient’s own healthy hair follicles to address specific cellular deficits. These products are built on the company’s proprietary manufacturing platforms. For additional information please visit www.replicel.com.

Friday, September 27, 2013

A stem cell research project takes an unexpected turn

A stem cell research project takes an unexpected turn


By Arielle Levin Becker Friday, September 2, 2011
Source: ctmirror.org  

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Thursday, June 27, 2013

Treating Baldness is "Not Like Growing Grass"

Treating Baldness is "Not Like Growing Grass"

Date: June 8, 2012
Source: scientificamerican.com

Progress may seem slow, but new treatments for hair loss are underway

Plain Grass lawn
More than 40 percent of men in the U.S. will show signs of male-pattern baldness sometime between the ages of 18 and 49. But studies looking at the genomes of this group of men have failed to turn up a genetic cause, which makes a true cure seem an unlikely prospect. 

Treatments for male-pattern baldness, also known as androgenic alopecia, may be forthcoming, however. Recent work is homing in on three types, including one that was reported in March in the journal Science. In the new paper, George Cotsarelis of the University of Pennsylvania and his team found that a compound known as prostaglandin D2 (PD2) was elevated in the blood of men with male-pattern baldness. When they blocked PD2 receptors in mice, they ensured that the hair did not stop growing. Those blockers could be applied topically, Cotsarelis says.

He is also working on growing new hair. Researchers have noticed that if you wound a mouse, the animal generates new hair follicles as part of the healing process. The new follicles come from skin cells that turn into hair follicles through what is called the Wnt-mediated signaling pathway. It is the same pathway that helps you generate new hairs naturally as they fall out. Cotsarelis is working with a company to replicate that process.

A third approach, called follicular neogenesis, would allow doctors to remove, multiply and then reimplant the stem cells found inside a person’s hair follicles. So far, though, when researchers remove the stem cells and culture them, the cells appear to “forget” they were ever hair cells. Researchers are now attempting to figure out how to restore their “memory.”

As scientists continue to search for treatments to androgenic alopecia, they recommend patience. “People think of it like growing grass or something, but it’s nothing like that,” Cotsarelis says. “It’s like trying to treat cancer; it’s a complicated process.”

This article was published in print as "It's Not "Like Growing Grass"."

Monday, May 13, 2013

Scientists' 'vampire treatment' for baldness

Scientists' 'vampire treatment' for baldness


By Jasper Copping
7:30AM BST 05 May 2013
Source: telegraph.co.uk

Scientists believe among others the treatment
 could help male-pattern baldness (Photo: gettyimages.com)
Scientists believe they may have hit upon a cure for baldness — but it is not for the faint-hearted.

Researchers found they were able to regrow hair on the bald patches on people’s heads by injecting them with a solution derived from their own blood.

The so-called “vampire” treatment involved taking blood from the patient and processing it in a machine that extracts “platelet-rich plasma” (PRP), which is then injected back into the head.

Scientists believe the solution then stimulates new stem cells below the skin which can aid the regrowth of hair.

Such “vampire” treatments are already used in some cosmetic procedures, where injections of PRP are used in an effort to reduce the effects of aging on the face and hands.

The new treatment could have helped Sir Elton John who invested in a hair transplant.

The research, published in the latest edition of the British Journal of Dermatology, was conducted among a group of people suffering from alopecia areata, which affects about 2 per cent of the population.

However, the scientists believe it could also help those suffering more common varieties, such as male pattern baldness. Dr Fabio Rinaldi said: “We think it can help to regrow hair on people with androgenic alopecia (male pattern baldness). We believe it is the best treatment available, apart from surgery.”

The study involved 45 patients, who received the injections on just one half of their head. Some were given the PRP, some were given a more traditional steroid treatment, while others received a placebo.

A total of three treatments were given to each patient, once a month. Hair growth was assessed by measuring the area where new hairs grew on the bald scalp. The PRP was found to lead to significant hair regrowth in the bald patches, compared with both the placebo and the steroid treatment.

The scientists, based at the International Hair Research Foundation and University of Brescia in Italy and the Hebrew University Medical Centre in Israel, are carrying out further research. They hope to be able to develop the treatment as a cream, to avoid the need for needles.

Nina Goad, of the British Association of Dermatologists, said: “Alopecia is known to lead to overwhelming effects on the patient’s quality of life and self-esteem. This could offer hope to thousands.”

Saturday, April 27, 2013

Japan study raises hopes of cure for baldness

Japan study raises hopes of cure for baldness

By AFP
Posted Wednesday, April 18 2012 at 12:36
Source: nation.co.ke
 
Japanese researchers have successfully grown hair on hairless mice by implanting follicles created from stem cells, they announced Wednesday, sparking new hopes of a cure for baldness.
 
Led by professor Takashi Tsuji from Tokyo University of Science, the team bioengineered hair follicles and transplanted them into the skin of hairless mice.
 
The creatures eventually grew hair, which continued regenerating in normal growth cycles after old hairs fell out.
 
When stem cells are grown into tissues or organs, they usually need to be extracted from embryos, but Tsuji and his researchers found hair follicles can be grown with adult stem cells, the study said.
 
"Our current study thus demonstrates the potential for not only hair regeneration therapy but also the realisation of bioengineered organ replacement using adult somatic stem cells," it said.
 
The combination of the new and existing technologies is expected to improve treatment for baldness, possibly allowing people to use their own cells for implants that will give them their hair back.
 
"We would like to start clinical research within three to five years, so that an actual treatment to general patients can start within a decade," said researcher Koh-ei Toyoshima.
 
The study is published in the online science magazine Nature Communications.